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mad leg nerve caused by b 12 vitaamin deficency in old diabetic patients taking metformin?

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These are results for mad leg nerve caused by b12 vitamin deficiency in old diabetic patients taking metformin?

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A B12 deficiency can cause nerve damage, a condition known as peripheral neuropathy, which can manifest as pain, numbness, or tingling, often in the legs and feet [1].

In older adults with diabetes who are taking metformin, several factors converge to make this a relevant concern:

Metformin Use: Long-term use of the diabetes medication metformin is a known risk factor for vitamin B12 deficiency because it can interfere with B12 absorption [1, 2].

Diabetes: Diabetes itself is a leading cause of peripheral neuropathy, often due to high blood sugar levels damaging nerves over time [2, 3].

Age: Older adults are generally more susceptible to B12 deficiency due to age-related changes in digestion and absorption [3].

When these factors are present, it can be difficult to distinguish whether the nerve symptoms are due to diabetic neuropathy, B12 deficiency neuropathy, or a combination of both [2].

It is important for older diabetic patients on metformin to be regularly screened for B12 deficiency. Treatment usually involves B12 supplements, which can prevent further nerve damage and potentially improve existing symptoms, though some severe damage may be permanent [1, 3].

Consult a healthcare professional for diagnosis and appropriate management.

Neuropsychiatric Disorders Associated With Vitamin B12 Deficiency ...

Jan 20, 2022 — Peripheral neuropathy is the most common presentation of vitamin B12 deficiency. Depending upon the type of nerve involved, it may present as pain, ...

National Institutes of Health (NIH) | (.gov)

The Relationship of Vitamin B12 and Sensory and Motor Peripheral ...

B12 deficiency may cause demyelination of nerves in the peripheral and central nervous system13 and has been associated with peripheral neuropathy, loss of sens...

National Institutes of Health (NIH) | (.gov)

Vitamin B12 Injections for Peripheral Neuropathy | Foot Nerve Pain Treatment UK

Vitamin B12 Injections for Peripheral Neuropathy: Evidence, Benefits & Timeline Peripheral neuropathy is a condition caused by damage to the peripheral nerves, ...

www.birminghamchiropodist.co.uk

Peripheral Neuropathy: What It Is, Symptoms & Treatment

The sensory symptoms of peripheral neuropathy include: - Tingling. This happens when there's a problem with nerves that carry signals to your brain. ...

Cleveland Clinic

Peripheral neuropathy - Symptoms and causes - Mayo Clinic

Sep 1, 2023 — Symptoms of peripheral neuropathy might include: Gradual onset of numbness, prickling, or tingling in your feet or hands. These sensations can spread...

Mayo Clinic

Prevalence of vitamin B12 deficiency in type 2 diabetic patients: A review

Vitamin B12 deficiency can lead to various complications in the body. The main features of vitamin B12 deficiency are the haematological and neuro cognitive dys...

International Journal of Home Science

Paper Title (use style: paper title)

the diabetes treatment metformin compared to those taking insulin or other biguanides. Age, poor nutrition, malabsorption, and some medications are all contribu...

University of Thi-Qar Journal of Science

Metformin-induced vitamin B12 deficiency can cause or worsen ...

Aug 14, 2022 — Abstract. Metformin blocks the absorption of vitamin B12 through a mechanism that has not been established but could be because of interference with...

National Institutes of Health (NIH) | (.gov)

Long-term metformin therapy and vitamin B12 deficiency: An ...

Jul 14, 2021 — However, over the last decades several observational studies and meta-analyses have reported a significant association between long-term metformin t...

National Institutes of Health (NIH) | (.gov)

Vitamin B12 and Diabetic Neuropathy

Mar 3, 2024 — If you have diabetes and take a medication like Metformin, you may have been told that you're at greater risk of being deficient in vitamin B12. This...

AZ Dietitians

Comparison of Patients Receiving Long-Term Metformin Therapy and Vitamin B12 Monitoring

Approximately 30% of patients taking metformin do not properly absorb vitamin B 12. This effect is most often seen after the patient has received long-term trea...

National Institutes of Health (NIH) | (.gov)

Diabetic Peripheral Neuropathy Treatments, Symptoms, & Causes

Jul 9, 2025 — Peripheral Neuropathy and Diabetes. Peripheral neuropathy is nerve damage caused by chronically high blood sugar and diabetes. It leads to numbness, ...

WebMD

Vitamin B12 deficiency in diabetic subjects taking metformin: A cross sectional study in a Lebanese cohort

Mar 14, 2018 — Since there is an overlap between the neurologic symptoms of vitamin B12 deficiency and those commonly associated with diabetes including paresthesi...

ScienceDirect.com

Revisiting Metformin: Annual Vitamin B12 Supplementation may become Mandatory with Long-Term Metformin Use

Even after measurement of low vit B 12 levels, the differential diagnosis from other causes of vit B 12 deficiency will be difficult to make. The fact that the ...

National Institutes of Health (NIH) | (.gov)

Association of Vitamin B12 and Metformin in Type II Diabetes Patients in Bahrain

Jun 13, 2018 — The fact that vitamin B12 deficient neuropathy and diabetic neuropathy cannot be distinguished clinically [7] renders it difficult to determine whic...

SciSpace

Long-term metformin therapy and vitamin B12 deficiency: An ...

Jul 14, 2021 — Even though definitive screening guidelines are lacking, the 2021 American Diabetes Association Standards of Medical Care in Diabetes recommend to c...

National Institutes of Health (NIH) | (.gov)

Long-term metformin therapy and vitamin B12 deficiency: An association to bear in mind

Jul 14, 2021 — In patients with metformin-induced vitamin B12 deficiency, vitamin B12 supplementation offers a simple, safe and effective means of preventing the d...

National Institutes of Health (NIH) | (.gov)

Metformin and Micronutrient Status in Type 2 Diabetes: Does Polypharmacy Involving Acid-Suppressing Medications Affect Vitamin B12 Levels?

Jun 17, 2020 — Supplementation of vitamin B 12, singularly or together with other interventions, has been shown to improve many symptoms of this condition.

National Institutes of Health (NIH) | (.gov)

Neuropathy Treatment for Legs & Feet

Mar 3, 2021 — Often, part of the disease process for neuropathy includes a deficiency of vitamin B12. Taking B12 supplements is therefore typically recommended as ...

Protalus

Neurological Manifestations of B12 Deficiency: Symptoms

Feb 24, 2025 — Can B12 deficiency cause permanent brain damage? Yes, if left untreated for a long time, B12 deficiency can lead to irreversible neurological damage...

Neurology Mobile

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National Institutes of Health (NIH) | (.gov)

https://pmc.ncbi.nlm.nih.gov

Vitamin B12 Deficiency and Clinical Neuropathy with ...

by MD Farooq · 2022 · Cited by 30 — In our study, we found that metformin use is associated with Vit B12 deficiency, which is dependent upon the cumulative dose of metformin.

Missing: mad ‎leg

GOV.UK

https://www.gov.uk

Metformin & Vitamin B12: New Advice for Monitoring Patients

Jun 20, 2022 — Decreased vitamin B12 levels, or vitamin B12 deficiency, is now considered to be a common side effect in patients on metformin treatment.

Missing: mad ‎leg

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